Research

Pathway Publications

Original Publications

  1. Dennis, M. D., Coleman, C. S., Berg, A., Jefferson, L. S., & Kimball, S. R. (2014). REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling. Science Signaling, 7(335), ra68. https://doi.org/10.1126/scisignal.2005103
  2. Dennis, M. D., Kimball, S. R., Fort, P. E., & Jefferson, L. S. (2015). Regulated in development and DNA damage 1 is necessary for hyperglycemia-induced vascular endothelial growth factor expression in the retina of diabetic rodents. The Journal of Biological Chemistry, 290(6), 3865–3874. https://doi.org/10.1074/jbc.M114.623058
  3. Quang, D. X., Erdos, M. R., Parker, S. C. J., & Collins, F. S. (2015). Motif signatures in stretch enhancers are enriched for disease-associated genetic variants. Epigenetics & Chromatin, 8, 23. https://doi.org/10.1186/s13072-015-0015-7
  4. Krishnan, N., Krishnan, K., Connors, C. R., Choy, M. S., Page, R., Peti, W., … Tonks, N. K. (2015). PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. The Journal of Clinical Investigation, 125(8), 3163–3177. https://doi.org/10.1172/JCI80323
  5. Krishnan, N., Koveal, D., Miller, D. H., Xue, B., Akshinthala, S. D., Kragelj, J., … Tonks, N. K. (2014). Targeting the disordered C terminus of PTP1B with an allosteric inhibitor. Nature Chemical Biology, 10(7), 558–566. https://doi.org/10.1038/nchembio.1528
  6. Yu, J., Zhang, Y., Ye, Y., DiSanto, R., Sun, W., Ranson, D., … Gu, Z. (2015). Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery. Proceedings of the National Academy of Sciences of the United States of America, 112(27), 8260–8265. https://doi.org/10.1073/pnas.1505405112
  7. Di, J., Yao, S., Ye, Y., Cui, Z., Yu, J., Ghosh, T. K., … Gu, Z. (2015). Stretch-Triggered Drug Delivery from Wearable Elastomer Films Containing Therapeutic Depots. ACS Nano, 9(9), 9407–9415. https://doi.org/10.1021/acsnano.5b03975
  8. Di, J., Yu, J., Ye, Y., Ranson, D., Jindal, A., Gu, Z. Engineering Synthetic Insulin-Secreting Cells Using Hyaluronic Acid Microgels Integrated with Glucose-Responsive Nanoparticles. Cellular and Molecular Bioengineering. 2015 (Cover Feature; Young Innovators Special Issue).
  9. Gao, M., Nguyen, T. T., Suckow, M. A., Wolter, W. R., Gooyit, M., Mobashery, S., & Chang, M. (2015). Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy. Proceedings of the National Academy of Sciences of the United States of America, 112(49), 15226–15231. https://doi.org/10.1073/pnas.1517847112
  10. Moore, J. A., Miller, W. P., & Dennis, M. D. (2016). Glucosamine induces REDD1 to suppress insulin action in retinal Müller cells. Cellular Signalling, 28(5), 384–390. https://doi.org/10.1016/j.cellsig.2016.01.017
  11. Delong, T., Wiles, T. A., Baker, R. L., Bradley, B., Barbour, G., Reisdorph, R., … Haskins, K. (2016). Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. Science (New York, N.Y.), 351(6274), 711–714. https://doi.org/10.1126/science.aad2791
  12. Miller, W. P., Mihailescu, M. L., Yang, C., Barber, A. J., Kimball, S. R., Jefferson, L. S., & Dennis, M. D. (2016). The Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual Dysfunction. Investigative Ophthalmology & Visual Science, 57(3), 1327–1337. https://doi.org/10.1167/iovs.15-18719
  13. Soares, M. A., Cohen, O. D., Low, Y. C., Sartor, R. A., Ellison, T., Anil, U., … Ceradini, D. J. (2016). Restoration of Nrf2 Signaling Normalizes the Regenerative Niche. Diabetes, 65(3), 633–646. https://doi.org/10.2337/db15-0453
  14. Ye, Y., Yu, J., Wang, C., Nguyen, N.-Y., Walker, G. M., Buse, J. B., & Gu, Z. (2016). Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery. Advanced Materials (Deerfield Beach, Fla.), 28(16), 3115–3121. https://doi.org/10.1002/adma.201506025
  15. Szodoray, P., Stanford, S. M., Molberg, Ø., Munthe, L. A., Bottini, N., & Nakken, B. (2016). T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity. The Journal of Allergy and Clinical Immunology, 138(3), 839-851.e8. https://doi.org/10.1016/j.jaci.2016.01.035
  16. Scott, L. J., Erdos, M. R., Huyghe, J. R., Welch, R. P., Beck, A. T., Wolford, B. N., … Parker, S. C. J. (2016). The genetic regulatory signature of type 2 diabetes in human skeletal muscle. Nature Communications, 7, 11764. https://doi.org/10.1038/ncomms11764
  17. Powe, C. E., Allard, C., Battista, M.-C., Doyon, M., Bouchard, L., Ecker, J. L., … Hivert, M.-F. (2016). Heterogeneous Contribution of Insulin Sensitivity and Secretion Defects to Gestational Diabetes Mellitus. Diabetes Care, 39(6), 1052–1055. https://doi.org/10.2337/dc15-2672
  18. White, P. J., Lapworth, A. L., An, J., Wang, L., McGarrah, R. W., Stevens, R. D., … Newgard, C. B. (2016). Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export. Molecular Metabolism, 5(7), 538–551. https://doi.org/10.1016/j.molmet.2016.04.006
  19. Tang, J. C., Drokhlyansky, E., Etemad, B., Rudolph, S., Guo, B., Wang, S., … Cepko, C. L. (2016). Detection and manipulation of live antigen-expressing cells using conditionally stable nanobodies. ELife, 5. https://doi.org/10.7554/eLife.15312
  20. Peck, B. C. E., Sincavage, J., Feinstein, S., Mah, A. T., Simmons, J. G., Lund, P. K., & Sethupathy, P. (2016). miR-30 Family Controls Proliferation and Differentiation of Intestinal Epithelial Cell Models by Directing a Broad Gene Expression Program That Includes SOX9 and the Ubiquitin Ligase Pathway. The Journal of Biological Chemistry, 291(31), 15975–15984. https://doi.org/10.1074/jbc.M116.733733
  21. Zimmerman, C. A., Lin, Y.-C., Leib, D. E., Guo, L., Huey, E. L., Daly, G. E., … Knight, Z. A. (2016). Thirst neurons anticipate the homeostatic consequences of eating and drinking. Nature, 537(7622), 680–684. https://doi.org/10.1038/nature18950
  22. Fuchsberger, C., Flannick, J., Teslovich, T. M., Mahajan, A., Agarwala, V., Gaulton, K. J., … McCarthy, M. I. (2016). The genetic architecture of type 2 diabetes. Nature, 536(7614), 41–47. https://doi.org/10.1038/nature18642
  23. Leib, D. E., & Knight, Z. A. (2016). Rapid Sensing of Dietary Amino Acid Deficiency Does Not Require GCN2. Cell Reports, 16(8), 2051–2052. https://doi.org/10.1016/j.celrep.2016.08.022
  24. Chen, Y., Lin, Y.-C., Zimmerman, C. A., Essner, R. A., & Knight, Z. A. (2016). Hunger neurons drive feeding through a sustained, positive reinforcement signal. ELife, 5. https://doi.org/10.7554/eLife.18640
  25. Kimball, S. R., Gordon, B. S., Moyer, J. E., Dennis, M. D., & Jefferson, L. S. (2016). Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation. Cellular Signalling, 28(8), 896–906. https://doi.org/10.1016/j.cellsig.2016.03.008
  26. Kim, H.-E., Grant, A. R., Simic, M. S., Kohnz, R. A., Nomura, D. K., Durieux, J., … Dillin, A. (2016). Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response. Cell, 166(6), 1539-1552.e16. https://doi.org/10.1016/j.cell.2016.08.027
  27. Tan, C. L., Cooke, E. K., Leib, D. E., Lin, Y.-C., Daly, G. E., Zimmerman, C. A., & Knight, Z. A. (2016). Warm-Sensitive Neurons that Control Body Temperature. Cell, 167(1), 47-59.e15. https://doi.org/10.1016/j.cell.2016.08.028
  28. Gwiazda, K. S., Grier, A. E., Sahni, J., Burleigh, S. M., Martin, U., Yang, J. G., … Scharenberg, A. M. (2016). High Efficiency CRISPR/Cas9-mediated Gene Editing in Primary Human T-cells Using Mutant Adenoviral E4orf6/E1b55k “Helper” Proteins. Molecular Therapy: The Journal of the American Society of Gene Therapy, 24(9), 1570–1580. https://doi.org/10.1038/mt.2016.105
  29. Cardenas, A., Allard, C., Doyon, M., Houseman, E. A., Bakulski, K. M., Perron, P., … Hivert, M.-F. (2016). Validation of a DNA methylation reference panel for the estimation of nucleated cells types in cord blood. Epigenetics, 11(11), 773–779.
  30. Babon, J. A. B., DeNicola, M. E., Blodgett, D. M., Crèvecoeur, I., Buttrick, T. S., Maehr, R., … Kent, S. C. (2016). Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nature Medicine, 22(12), 1482–1487. https://doi.org/10.1038/nm.4203
  31. Cardenas, A., Allard, C., Doyon, M., Houseman, E. A., Bakulski, K. M., Perron, P., … Hivert, M.-F. (2016). Validation of a DNA methylation reference panel for the estimation of nucleated cells types in cord blood. Epigenetics, 11(11), 773–779. https://doi.org/10.1080/15592294.2016.1233091
  32. Black, A. J., Gordon, B. S., Dennis, M. D., Jefferson, L. S., & Kimball, S. R. (2016). Regulation of protein and mRNA expression of the mTORC1 repressor REDD1 in response to leucine and serum. Biochemistry and Biophysics Reports, 8, 296–301. https://doi.org/10.1016/j.bbrep.2016.10.003
  33. Patenaude, J., Lacerte, G., Lacroix, M., Guillemette, L., Allard, C., Doyon, M., … Hivert, M.-F. (2017). Associations of Maternal Leptin with Neonatal Adiposity Differ according to Pregravid Weight. Neonatology, 111(4), 344–352. https://doi.org/10.1159/000454756
  34. Hu, X., Yu, J., Qian, C., Lu, Y., Kahkoska, A. R., Xie, Z., … Gu, Z. (2017). H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery. ACS Nano, 11(1), 613–620. https://doi.org/10.1021/acsnano.6b06892
  35. Douglass, J. D., Dorfman, M. D., Fasnacht, R., Shaffer, L. D., & Thaler, J. P. (2017). Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation. Molecular Metabolism, 6(4), 366–373. https://doi.org/10.1016/j.molmet.2017.01.010
  36. Miller, W. P., Ravi, S., Martin, T. D., Kimball, S. R., & Dennis, M. D. (2017). Activation of the Stress Response Kinase JNK (c-Jun N-terminal Kinase) Attenuates Insulin Action in Retina through a p70S6K1-dependent Mechanism. The Journal of Biological Chemistry, 292(5), 1591–1602. https://doi.org/10.1074/jbc.M116.760868
  37. Choy, M. S., Li, Y., Machado, L. E. S. F., Kunze, M. B. A., Connors, C. R., Wei, X., … Peti, W. (2017). Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Molecular Cell, 65(4), 644-658.e5. https://doi.org/10.1016/j.molcel.2017.01.014
  38. Peck, B. C. E., Mah, A. T., Pitman, W. A., Ding, S., Lund, P. K., & Sethupathy, P. (2017). Functional Transcriptomics in Diverse Intestinal Epithelial Cell Types Reveals Robust MicroRNA Sensitivity in Intestinal Stem Cells to Microbial Status. The Journal of Biological Chemistry, 292(7), 2586–2600. https://doi.org/10.1074/jbc.M116.770099
  39. Dorfman, M. D., Krull, J. E., Douglass, J. D., Fasnacht, R., Lara-Lince, F., Meek, T. H., … Thaler, J. P. (2017). Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice. Nature Communications, 8, 14556. https://doi.org/10.1038/ncomms14556
  40. Varshney, A., Scott, L. J., Welch, R. P., Erdos, M. R., Chines, P. S., Narisu, N., … Stitzel, M. L. (2017). Genetic regulatory signatures underlying islet gene expression and type 2 diabetes. Proceedings of the National Academy of Sciences of the United States of America, 114(9), 2301–2306. https://doi.org/10.1073/pnas.1621192114
  41. Wiles, T. A., Delong, T., Baker, R. L., Bradley, B., Barbour, G., Powell, R. L., … Haskins, K. (2017). An insulin-IAPP hybrid peptide is an endogenous antigen for CD4 T cells in the non-obese diabetic mouse. Journal of Autoimmunity, 78, 11–18. https://doi.org/10.1016/j.jaut.2016.10.007
  42. Dorfman, M. D., Krull, J. E., Scarlett, J. M., Guyenet, S. J., Sajan, M. P., Damian, V., … Thaler, J. P. (2017). Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity. Diabetes, 66(4), 920–934. https://doi.org/10.2337/db16-0482
  43. Machado, L. E. S. F., Shen, T.-L., Page, R., & Peti, W. (2017). The KIM-family protein-tyrosine phosphatases use distinct reversible oxidation intermediates: Intramolecular or intermolecular disulfide bond formation. The Journal of Biological Chemistry, 292(21), 8786–8796. https://doi.org/10.1074/jbc.M116.774174
  44. Wang, C., Ye, Y., Sun, W., Yu, J., Wang, J., Lawrence, D. S., … Gu, Z. (2017). Red Blood Cells for Glucose-Responsive Insulin Delivery. Advanced Materials (Deerfield Beach, Fla.), 29(18). https://doi.org/10.1002/adma.201606617
  45. Hivert, M.-F., Scholtens, D. M., Allard, C., Nodzenski, M., Bouchard, L., Brisson, D., … Lowe, W. L. (2017). Genetic determinants of adiponectin regulation revealed by pregnancy. Obesity (Silver Spring, Md.), 25(5), 935–944. https://doi.org/10.1002/oby.21805
  46. Stanford, S. M., Aleshin, A. E., Zhang, V., Ardecky, R. J., Hedrick, M. P., Zou, J., … Bottini, N. (2017). Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nature Chemical Biology, 13(6), 624–632. https://doi.org/10.1038/nchembio.2344
  47. Rabbani, P. S., Zhou, A., Borab, Z. M., Frezzo, J. A., Srivastava, N., More, H. T., … Ceradini, D. J. (2017). Novel lipoproteoplex delivers Keap1 siRNA based gene therapy to accelerate diabetic wound healing. Biomaterials, 132, 1–15. https://doi.org/10.1016/j.biomaterials.2017.04.001
  48. Pereira, M. M. A., Mahú, I., Seixas, E., Martinéz-Sánchez, N., Kubasova, N., Pirzgalska, R. M., … Domingos, A. I. (2017). A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages. Nature Communications, 8, 14967. https://doi.org/10.1038/ncomms14967
  49. Valdearcos, M., Douglass, J. D., Robblee, M. M., Dorfman, M. D., Stifler, D. R., Bennett, M. L., … Koliwad, S. K. (2017). Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility. Cell Metabolism, 26(1), 185-197.e3. https://doi.org/10.1016/j.cmet.2017.05.015
  50. Riera, C. E., Tsaousidou, E., Halloran, J., Follett, P., Hahn, O., Pereira, M. M. A., … Dillin, A. (2017). The Sense of Smell Impacts Metabolic Health and Obesity. Cell Metabolism, 26(1), 198-211.e5. https://doi.org/10.1016/j.cmet.2017.06.015
  51. Flak, J. N., Arble, D., Pan, W., Patterson, C., Lanigan, T., Goforth, P. B., … Myers, M. G. (2017). A leptin-regulated circuit controls glucose mobilization during noxious stimuli. The Journal of Clinical Investigation, 127(8), 3103–3113. https://doi.org/10.1172/JCI90147
  52. Wheeler, E., Leong, A., Liu, C.-T., Hivert, M.-F., Strawbridge, R. J., Podmore, C., … Meigs, J. B. (2017). Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. PLoS Medicine, 14(9), e1002383. https://doi.org/10.1371/journal.pmed.1002383
  53. Yan, X., Wang, Z., Westberg-Rasmussen, S., Tarbier, M., Rathjen, T., Tattikota, S. G., … Poy, M. N. (2017). Differential Impact of Glucose Administered Intravenously and Orally on Circulating miR-375 Levels in Human Subjects. The Journal of Clinical Endocrinology and Metabolism, 102(10), 3749–3755. https://doi.org/10.1210/jc.2017-01365
  54. Sharp, G. C., Salas, L. A., Monnereau, C., Allard, C., Yousefi, P., Everson, T. M., … Relton, C. L. (2017). Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium. Human Molecular Genetics, 26(20), 4067–4085. https://doi.org/10.1093/hmg/ddx290
  55. Beutler, L. R., Chen, Y., Ahn, J. S., Lin, Y.-C., Essner, R. A., & Knight, Z. A. (2017). Dynamics of Gut-Brain Communication Underlying Hunger. Neuron, 96(2), 461-475.e5. https://doi.org/10.1016/j.neuron.2017.09.043
  56. Choy, M. S., Swingle, M., D’Arcy, B., Abney, K., Rusin, S. F., Kettenbach, A. N., … Peti, W. (2017). PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors. Journal of the American Chemical Society, 139(49), 17703–17706. https://doi.org/10.1021/jacs.7b09368
  57. Flannick, J., Fuchsberger, C., Mahajan, A., Teslovich, T. M., Agarwala, V., Gaulton, K. J., … McCarthy, M. I. (2017). Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 4, 170179. https://doi.org/10.1038/sdata.2017.179
  58. Machado, L. E. S. F., Page, R., & Peti, W. (2018). 1H, 15N and 13C sequence specific backbone assignment of the vanadate inhibited hematopoietic tyrosine phosphatase. Biomolecular NMR Assignments, 12(1), 5–9. https://doi.org/10.1007/s12104-017-9770-7
  59. Miller, W. P., Yang, C., Mihailescu, M. L., Moore, J. A., Dai, W., Barber, A. J., & Dennis, M. D. (2018). Deletion of the Akt/mTORC1 Repressor REDD1 Prevents Visual Dysfunction in a Rodent Model of Type 1 Diabetes. Diabetes, 67(1), 110–119. https://doi.org/10.2337/db17-0728
  60. Zillikens, M. C., Demissie, S., Hsu, Y.-H., Yerges-Armstrong, L. M., Chou, W.-C., Stolk, L., … Kiel, D. P. (2017). Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nature Communications, 8(1), 80. https://doi.org/10.1038/s41467-017-00031-7
  61. Roman, T. S., Cannon, M. E., Vadlamudi, S., Buchkovich, M. L., Wolford, B. N., Welch, R. P., … Mohlke, K. L. (2017). A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus. Diabetes, 66(9), 2521–2530. https://doi.org/10.2337/db17-0464
  62. Leib, D. E., Zimmerman, C. A., Poormoghaddam, A., Huey, E. L., Ahn, J. S., Lin, Y.-C., … Knight, Z. A. (2017). The Forebrain Thirst Circuit Drives Drinking through Negative Reinforcement. Neuron, 96(6), 1272-1281.e4. https://doi.org/10.1016/j.neuron.2017.11.041
  63. Chen, Z., Wang, J., Sun, W., Archibong, E., Kahkoska, A. R., Zhang, X., … Gu, Z. (2018). Synthetic beta cells for fusion-mediated dynamic insulin secretion. Nature Chemical Biology, 14(1), 86–93. https://doi.org/10.1038/nchembio.2511
  64. Nguyen, T. T., Ding, D., Wolter, W. R., Champion, M. M., Hesek, D., Lee, M., … Chang, M. (2018). Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers. European Journal of Pharmacology, 834, 77–83. https://doi.org/10.1016/j.ejphar.2018.07.014
  65. White, P. J., McGarrah, R. W., Grimsrud, P. A., Tso, S.-C., Yang, W.-H., Haldeman, J. M., … Newgard, C. B. (2018). The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase. Cell Metabolism, 27(6), 1281-1293.e7. https://doi.org/10.1016/j.cmet.2018.04.015
  66. Rabbani, P. S., Ellison, T., Waqas, B., Sultan, D., Abdou, S., David, J. A., … Ceradini, D. J. (2018). Targeted Nrf2 activation therapy with RTA 408 enhances regenerative capacity of diabetic wounds. Diabetes Research and Clinical Practice, 139, 11–23. https://doi.org/10.1016/j.diabres.2018.02.021
  67. Fang, C., Zhong, H., Lin, Y., Chen, B., Han, M., Ren, H., … Li, J. (2018). Assessment of the cPAS-based BGISEQ-500 platform for metagenomic sequencing. GigaScience, 7(3), 1–8. https://doi.org/10.1093/gigascience/gix133
  68. Luber, J. M., Tierney, B. T., Cofer, E. M., Patel, C. J., & Kostic, A. D. (2018). Aether: leveraging linear programming for optimal cloud computing in genomics. Bioinformatics (Oxford, England), 34(9), 1565–1567. https://doi.org/10.1093/bioinformatics/btx787
  69. Pan, W., Adams, J. M., Allison, M. B., Patterson, C., Flak, J. N., Jones, J., … Myers, M. G. (2018). Essential Role for Hypothalamic Calcitonin Receptor‒Expressing Neurons in the Control of Food Intake by Leptin. Endocrinology, 159(4), 1860–1872. https://doi.org/10.1210/en.2017-03259
  70. Meek, T. H., Matsen, M. E., Faber, C. L., Samstag, C. L., Damian, V., Nguyen, H. T., … Morton, G. J. (2018). In Uncontrolled Diabetes, Hyperglucagonemia and Ketosis Result From Deficient Leptin Action in the Parabrachial Nucleus. Endocrinology, 159(4), 1585–1594. https://doi.org/10.1210/en.2017-03199
  71. Kycia, I., Wolford, B. N., Huyghe, J. R., Fuchsberger, C., Vadlamudi, S., Kursawe, R., … Stitzel, M. L. (2018). A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression. American Journal of Human Genetics, 102(4), 620–635. https://doi.org/10.1016/j.ajhg.2018.02.020
  72. Dai, W., Dierschke, S. K., Toro, A. L., & Dennis, M. D. (2018). Consumption of a high fat diet promotes protein O-GlcNAcylation in mouse retina via NR4A1-dependent GFAT2 expression. Biochimica Et Biophysica Acta. Molecular Basis of Disease, 1864(12), 3568–3576. https://doi.org/10.1016/j.bbadis.2018.09.006
  73. Dai, W., Miller, W. P., Toro, A. L., Black, A. J., Dierschke, S. K., Feehan, R. P., … Dennis, M. D. (2018). Deletion of the stress-response protein REDD1 promotes ceramide-induced retinal cell death and JNK activation. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, fj201800413RR. https://doi.org/10.1096/fj.201800413RR
  74. Taylor, D. L., Knowles, D. A., Scott, L. J., Ramirez, A. H., Casale, F. P., Wolford, B. N., … Collins, F. S. (2018). Interactions between genetic variation and cellular environment in skeletal muscle gene expression. PloS One, 13(4), e0195788. https://doi.org/10.1371/journal.pone.0195788
  75. Zou, L. S., Erdos, M. R., Taylor, D. L., Chines, P. S., Varshney, A., McDonnell Genome Institute, … Didion, J. P. (2018). BoostMe accurately predicts DNA methylation values in whole-genome bisulfite sequencing of multiple human tissues. BMC Genomics, 19(1), 390. https://doi.org/10.1186/s12864-018-4766-y
  76. Orchard, P., White, J. S., Thomas, P. E., Mychalowych, A., Kiseleva, A., Hensley, J., … Keegan, C. E. (2018). Genome-wide chromatin accessibility and transcriptome profiling show minimal epigenome changes and coordinated transcriptional dysregulation of hedgehog signaling in Danforth’s short tail mice. Human Molecular Genetics. https://doi.org/10.1093/hmg/ddy378
  77. Powe, C. E., Nodzenski, M., Talbot, O., Allard, C., Briggs, C., Leya, M. V., … Hivert, M.-F. (2018). Genetic Determinants of Glycemic Traits and the Risk of Gestational Diabetes Mellitus. Diabetes. https://doi.org/10.2337/db18-0203
  78. Cardenas, A., Gagné-Ouellet, V., Allard, C., Brisson, D., Perron, P., Bouchard, L., & Hivert, M.-F. (2018). Placental DNA Methylation Adaptation to Maternal Glycemic Response in Pregnancy. Diabetes, 67(8), 1673–1683. https://doi.org/10.2337/db18-0123
  79. Keith, B. P., Barrow, J. B., Toyonaga, T., Kazgan, N., O’Connor, M. H., Shah, N. D., … Sheikh, S. Z. (2018). Colonic epithelial miR-31 associates with the development of Crohn’s phenotypes. JCI Insight, 3(19). https://doi.org/10.1172/jci.insight.122788
  80. Nguyen, T. T., Ding, D., Wolter, W. R., Pérez, R. L., Champion, M. M., Mahasenan, K. V., … Chang, M. (2018). Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing. Journal of Medicinal Chemistry, 61(19), 8825–8837. https://doi.org/10.1021/acs.jmedchem.8b01005
  81. Fujisaka, S., Avila-Pacheco, J., Soto, M., Kostic, A., Dreyfuss, J. M., Pan, H., … Kahn, C. R. (2018). Diet, Genetics, and the Gut Microbiome Drive Dynamic Changes in Plasma Metabolites. Cell Reports, 22(11), 3072–3086. https://doi.org/10.1016/j.celrep.2018.02.060
  82. Kim, H., Theogarajan, L. S., & Pennathur, S. (2018). A repeatable and scalable fabrication method for sharp, hollow silicon microneedles. Journal of Micromechanics and Microengineering, 28(3), 035007. https://doi.org/10.1088/1361-6439/aaa6a8
  83. Khetan, S., Kursawe, R., Youn, A., Lawlor, N., Jillette, A., Marquez, E. J., … Stitzel, M. L. (2018). Type 2 Diabetes-Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets. Diabetes, 67(11), 2466–2477. https://doi.org/10.2337/db18-0393
  84. Maeder, C. I., Kim, J.-I., Liang, X., Kaganovsky, K., Shen, A., Li, Q., … Shen, K. (2018). The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival. Cell, 174(6), 1436-1449.e20. https://doi.org/10.1016/j.cell.2018.07.046
  85. Huang, C., Walker, E. M., Dadi, P. K., Hu, R., Xu, Y., Zhang, W., … Gu, G. (2018). Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles. Developmental Cell, 45(3), 347-361.e5. https://doi.org/10.1016/j.devcel.2018.03.013
  86. Lin, S., Nascimento, E. M., Gajera, C. R., Chen, L., Neuhöfer, P., Garbuzov, A., … Artandi, S. E. (2018). Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury. Nature, 556(7700), 244–248. https://doi.org/10.1038/s41586-018-0004-7
  87. Rabbani, P. S., Soares, M. A., Hameedi, S. G., Kadle, R. L., Mubasher, A., Kowzun, M., & Ceradini, D. J. (2018). Dysregulation of Nrf2/Keap1 Redox Pathway in Diabetes Affects Multipotency of Stromal Cells. Diabetes. https://doi.org/10.2337/db18-0232
  88. Kantar, R. S., Rifkin, W. J., Wilson, S. C., David, J. A., Diaz-Siso, J. R., Levine, J. P., … Ceradini, D. J. (2018). Abdominal Panniculectomy: Determining the Impact of Diabetes on Complications and Risk Factors for Adverse Events. Plastic and Reconstructive Surgery, 142(4), 462e-471e. https://doi.org/10.1097/PRS.0000000000004732
  89. Baker, R. L., Jamison, B. L., Wiles, T. A., Lindsay, R. S., Barbour, G., Bradley, B., … Haskins, K. (2018). CD4 T Cells Reactive to Hybrid Insulin Peptides Are Indicators of Disease Activity in the NOD Mouse. Diabetes, 67(9), 1836–1846. https://doi.org/10.2337/db18-0200
  90. Kumar, G. S., Choy, M. S., Koveal, D. M., Lorinsky, M. K., Lyons, S. P., Kettenbach, A. N., … Peti, W. (2018). Identification of the substrate recruitment mechanism of the muscle glycogen protein phosphatase 1 holoenzyme. Science Advances, 4(11), eaau6044. https://doi.org/10.1126/sciadv.aau6044
  91. Luo, S., Alves, J., Hardy, K., Wang, X., Monterosso, J., Xiang, A. H., & Page, K. A. (2018). Neural processing of food cues in pre-pubertal children. Pediatric Obesity. https://doi.org/10.1111/ijpo.12435
  92. Wang, J., Ye, Y., Yu, J., Kahkoska, A. R., Zhang, X., Wang, C., … Gu, Z. (2018). Core-Shell Microneedle Gel for Self-Regulated Insulin Delivery. ACS Nano, 12(3), 2466–2473. https://doi.org/10.1021/acsnano.7b08152
  93. Chen, G., Yu, J., & Gu, Z. (2018). Glucose-Responsive Microneedle Patches for Diabetes Treatment. Journal of Diabetes Science and Technology, 1932296818778607. https://doi.org/10.1177/1932296818778607
  94. Lawlor, N., Márquez, E. J., Orchard, P., Narisu, N., Shamim, M. S., Thibodeau, A., … Stitzel, M. L. (2019). Multiomic Profiling Identifies cis-Regulatory Networks Underlying Human Pancreatic β Cell Identity and Function. Cell Reports, 26(3), 788-801.e6. https://doi.org/10.1016/j.celrep.2018.12.083
  95. Kim, H., & Jaffrey, S. R. (2019). A Fluorogenic RNA-Based Sensor Activated by Metabolite-Induced RNA Dimerization. Cell Chemical Biology. https://doi.org/10.1016/j.chembiol.2019.09.013
  96. Chen, Y., Essner, R. A., Kosar, S., Miller, O. H., Lin, Y.-C., Mesgarzadeh, S., & Knight, Z. A. (2019). Sustained NPY signaling enables AgRP neurons to drive feeding. ELife, 8. https://doi.org/10.7554/eLife.46348
  97. Zimmerman, C. A., Huey, E. L., Ahn, J. S., Beutler, L. R., Tan, C. L., Kosar, S., … Knight, Z. A. (2019). A gut-to-brain signal of fluid osmolarity controls thirst satiation. Nature, 568(7750), 98–102. https://doi.org/10.1038/s41586-019-1066-x
  98. Bai, L., Mesgarzadeh, S., Ramesh, K. S., Huey, E. L., Liu, Y., Gray, L. A., … Knight, Z. A. (2019). Genetic Identification of Vagal Sensory Neurons That Control Feeding. Cell, 179(5), 1129-1143.e23. https://doi.org/10.1016/j.cell.2019.10.031
  99. Singh, A. P., Hung, Y.-H., Shanahan, M. T., Kanke, M., Bonfini, A., Dame, M. K., … Sethupathy, P. (2019). Enteroendocrine progenitor cell enriched miR-7 regulates intestinal epithelial proliferation in an Xiap-dependent manner. Cellular and Molecular Gastroenterology and Hepatology. https://doi.org/10.1016/j.jcmgh.2019.11.001
  100. Hung, Y.-H., Kanke, M., Kurtz, C. L., Cubitt, R. L., Bunaciu, R. P., Zhou, L., … Sethupathy, P. (2019). MiR-29 Regulates de novo Lipogenesis in the Liver and Circulating Triglyceride Levels in a Sirt1-Dependent Manner. Frontiers in Physiology, 10, 1367. https://doi.org/10.3389/fphys.2019.01367
  101. Huang, R., Zong, X., Nadesan, P., Huebner, J. L., Kraus, V. B., White, J. P., … Baht, G. S. (2019). Lowering circulating apolipoprotein E levels improves aged bone fracture healing. JCI Insight, 4(18). https://doi.org/10.1172/jci.insight.129144
  102. Yoneshiro, T., Wang, Q., Tajima, K., Matsushita, M., Maki, H., Igarashi, K., … Kajimura, S. (2019). BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature, 572(7771), 614–619. https://doi.org/10.1038/s41586-019-1503-x
  103. Hung, Y.-H., Kanke, M., Kurtz, C. L., Cubitt, R., Bunaciu, R. P., Miao, J., … Sethupathy, P. (2019). Acute suppression of insulin resistance-associated hepatic miR-29 in vivo improves glycemic control in adult mice. Physiological Genomics, 51(8), 379–389. https://doi.org/10.1152/physiolgenomics.00037.2019
  104. Ericksen, R. E., Lim, S. L., McDonnell, E., Shuen, W. H., Vadiveloo, M., White, P. J., … Han, W. (2019). Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression. Cell Metabolism, 29(5), 1151-1165.e6. https://doi.org/10.1016/j.cmet.2018.12.020
  105. Schneeberger, M., Parolari, L., Das Banerjee, T., Bhave, V., Wang, P., Patel, B., … Nectow, A. R. (2019). Regulation of Energy Expenditure by Brainstem GABA Neurons. Cell, 178(3), 672-685.e12. https://doi.org/10.1016/j.cell.2019.05.048
  106. Li, M. M., Madara, J. C., Steger, J. S., Krashes, M. J., Balthasar, N., Campbell, J. N., … Lowell, B. B. (2019). The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits. Neuron, 102(3), 653-667.e6. https://doi.org/10.1016/j.neuron.2019.02.028
  107. Ma, B., Allard, C., Bouchard, L., Perron, P., Mittleman, M. A., Hivert, M.-F., & Liang, L. (2019). Locus-specific DNA methylation prediction in cord blood and placenta. Epigenetics, 14(4), 405–420. 
  108. Küpers, L. K., Monnereau, C., Sharp, G. C., Yousefi, P., Salas, L. A., Ghantous, A., … Felix, J. F. (2019). Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight. Nature Communications, 10(1), 1893. https://doi.org/10.1038/s41467-019-09671-3
  109. Cardenas, A., Lutz, S. M., Everson, T. M., Perron, P., Bouchard, L., & Hivert, M.-F. (2019). Mediation by Placental DNA Methylation of the Association of Prenatal Maternal Smoking and Birth Weight. American Journal of Epidemiology, 188(11), 1878–1886. https://doi.org/10.1093/aje/kwz184
  110. Breton, E., Gagné-Ouellet, V., Thibeault, K., Guérin, R., Van Lieshout, R., Perron, P., … Bouchard, L. (2019). Placental NEGR1 DNA methylation is associated with BMI and neurodevelopment in preschool-age children. Epigenetics, 1–13.
  111. Fernandez-Jimenez, N., Allard, C., Bouchard, L., Perron, P., Bustamante, M., Bilbao, J. R., & Hivert, M.-F. (2019). Comparison of Illumina 450K and EPIC arrays in placental DNA methylation. Epigenetics, 14(12), 1177–1182.
  112. Layton, J., Powe, C., Allard, C., Battista, M.-C., Doyon, M., Bouchard, L., … Hivert, M.-F. (2019). Maternal lipid profile differs by gestational diabetes physiologic subtype. Metabolism: Clinical and Experimental, 91, 39–42. https://doi.org/10.1016/j.metabol.2018.11.008
  113. Miller, W. P., Toro, A. L., Barber, A. J., & Dennis, M. D. (2019). REDD1 Activates a ROS-Generating Feedback Loop in the Retina of Diabetic Mice. Investigative Ophthalmology & Visual Science, 60(6), 2369–2379. https://doi.org/10.1167/iovs.19-26606
  114. Dierschke, S. K., Miller, W. P., Favate, J. S., Shah, P., Imamura Kawasawa, Y., Salzberg, A. C., … Dennis, M. D. (2019). O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1-dependent mitochondrial dysfunction in the retina. The Journal of Biological Chemistry, 294(14), 5508–5520. https://doi.org/10.1074/jbc.RA119.007494
  115. Liu, J., Banerjee, A., Herring, C. A., Attalla, J., Hu, R., Xu, Y., … Gu, G. (2019). Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity. Developmental Cell, 48(1), 49-63.e7. https://doi.org/10.1016/j.devcel.2018.11.048
  116. Kim, N. Y., Goddard, T. N., Sohn, S., Spiegel, D. A., & Crawford, J. M. (2019). Biocatalytic Reversal of Advanced Glycation End Product Modification. Chembiochem: A European Journal of Chemical Biology, 20(18), 2402–2410. https://doi.org/10.1002/cbic.201900158
  117. Sabbasani, V. R., Wang, K.-P., Streeter, M. D., & Spiegel, D. A. (2019). One-Step Synthesis of 2,5-Diaminoimidazoles and Total Synthesis of Methylglyoxal-Derived Imidazolium Crosslink (MODIC). Angewandte Chemie (International Ed. in English). https://doi.org/10.1002/anie.201911156
  118. Tierney, B. T., Yang, Z., Luber, J. M., Beaudin, M., Wibowo, M. C., Baek, C., … Kostic, A. D. (2019). The Landscape of Genetic Content in the Gut and Oral Human Microbiome. Cell Host & Microbe, 26(2), 283-295.e8. https://doi.org/10.1016/j.chom.2019.07.008
  119. Mallick, H., Franzosa, E. A., Mclver, L. J., Banerjee, S., Sirota-Madi, A., Kostic, A. D., … Huttenhower, C. (2019). Predictive metabolomic profiling of microbial communities using amplicon or metagenomic sequences. Nature Communications, 10(1), 3136. https://doi.org/10.1038/s41467-019-10927-1
  120. Scheiman, J., Luber, J. M., Chavkin, T. A., MacDonald, T., Tung, A., Pham, L.-D., … Kostic, A. D. (2019). Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism. Nature Medicine, 25(7), 1104–1109. https://doi.org/10.1038/s41591-019-0485-4
  121. Brown, E. M., Ke, X., Hitchcock, D., Jeanfavre, S., Avila-Pacheco, J., Nakata, T., … Xavier, R. J. (2019). Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis. Cell Host & Microbe, 25(5), 668-680.e7. https://doi.org/10.1016/j.chom.2019.04.002
  122. Lavoie, S., Conway, K. L., Lassen, K. G., Jijon, H. B., Pan, H., Chun, E., … Xavier, R. J. (2019). The Crohn’s disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response. ELife, 8. https://doi.org/10.7554/eLife.39982
  123. Scida, K., Eden, A., Arroyo-Currás, N., MacKenzie, S., Satik, Y., Meinhart, C. D., … Pennathur, S. (2019). Fluorescence-Based Observation of Transient Electrochemical and Electrokinetic Effects at Nanoconfined Bipolar Electrodes. ACS Applied Materials & Interfaces, 11(14), 13777–13786. https://doi.org/10.1021/acsami.9b01339
  124. Wang, B., Chou, K.-H., Queenan, B. N., Pennathur, S., & Bazan, G. C. (2019). Molecular Design of a New Diboronic Acid for the Electrohydrodynamic Monitoring of Glucose. Angewandte Chemie (International Ed. in English), 58(31), 10612–10615. https://doi.org/10.1002/anie.201904595
  125. Eden, A., Scida, K., Arroyo-Currás, N., Eijkel, J. C. T., Meinhart, C. D., & Pennathur, S. (2019). Modeling Faradaic Reactions and Electrokinetic Phenomena at a Nanochannel-Confined Bipolar Electrode. The Journal of Physical Chemistry C, 123(9), 5353–5364. https://doi.org/10.1021/acs.jpcc.8b10473
  126. Nguyen, T. T., Jones, J. I., Wolter, W. R., Pérez, R. L., Schroeder, V. A., Champion, M. M., … Chang, M. (2019). Hyperbaric oxygen therapy accelerates wound healing in diabetic mice by decreasing active matrix metalloproteinase-9. Wound Repair and Regeneration: Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. https://doi.org/10.1111/wrr.12782
  127. Varshney, A., VanRenterghem, H., Orchard, P., Boyle, A. P., Stitzel, M. L., Ucar, D., & Parker, S. C. J. (2019). Cell Specificity of Human Regulatory Annotations and Their Genetic Effects on Gene Expression. Genetics, 211(2), 549–562. https://doi.org/10.1534/genetics.118.301525
  128. Taylor, D. L., Jackson, A. U., Narisu, N., Hemani, G., Erdos, M. R., Chines, P. S., … Collins, F. S. (2019). Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America, 116(22), 10883–10888. https://doi.org/10.1073/pnas.1814263116
  129. Baker, R. L., Rihanek, M., Hohenstein, A. C., Nakayama, M., Michels, A., Gottlieb, P. A., … Delong, T. (2019). Hybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes. Diabetes, 68(9), 1830–1840. https://doi.org/10.2337/db19-0128

Reviews

  1. Peti, W., & Page, R. (2015). Strategies to make protein serine/threonine (PP1, calcineurin) and tyrosine phosphatases (PTP1B) druggable: achieving specificity by targeting substrate and regulatory protein interaction sites. Bioorganic & Medicinal Chemistry, 23(12), 2781–2785. https://doi.org/10.1016/j.bmc.2015.02.040
  2. Niederriter, A. R., Varshney, A., Parker, S. C. J., & Martin, D. M. (2015). Super Enhancers in Cancers, Complex Disease, and Developmental Disorders. Genes, 6(4), 1183–1200. https://doi.org/10.3390/genes6041183
  3. Riera, C. E., & Dillin, A. (2015). Tipping the metabolic scales towards increased longevity in mammals. Nature Cell Biology, 17(3), 196–203. https://doi.org/10.1038/ncb3107
  4. Riera, C. E., & Dillin, A. (2016). Emerging Role of Sensory Perception in Aging and Metabolism. Trends in Endocrinology and Metabolism: TEM, 27(5), 294–303. https://doi.org/10.1016/j.tem.2016.03.007
  5. Chang, M. (2016). Restructuring of the extracellular matrix in diabetic wounds and healing: A perspective. Pharmacological Research, 107, 243–248. https://doi.org/10.1016/j.phrs.2016.03.008
  6. Sethupathy, P. (2016). The Promise and Challenge of Therapeutic MicroRNA Silencing in Diabetes and Metabolic Diseases. Current Diabetes Reports, 16(6), 52. https://doi.org/10.1007/s11892-016-0745-3
  7. Nguyen, T. T.; Mobashery, S.; Chang, M. Roles of Matrix Metalloproteinases in Cutaneous Wound Healing. In "Wound Healing: New Insights into Ancient Challenges", Alexandrescu, V. A. (Editor), 2016, Chapter 3, p. 37-71, http://dx.doi.org/10.5772/64611. InTech Publisher, ISBN 978-953-51-2679-9.
  8. Meisel, J. E., & Chang, M. (2017). Selective small-molecule inhibitors as chemical tools to define the roles of matrix metalloproteinases in disease. Biochimica Et Biophysica Acta, 1864(11 Pt A), 2001–2014. https://doi.org/10.1016/j.bbamcr.2017.04.011
  9. David, J. A., Rifkin, W. J., Rabbani, P. S., & Ceradini, D. J. (2017). The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus. Journal of Diabetes Research, 2017, 4826724. https://doi.org/10.1155/2017/4826724
  10. Choi, C. H. J., & Cohen, P. (2017). Adipose crosstalk with other cell types in health and disease. Experimental Cell Research, 360(1), 6–11. https://doi.org/10.1016/j.yexcr.2017.04.022
  11. Peck, B. C. E., Shanahan, M. T., Singh, A. P., & Sethupathy, P. (2017). Gut Microbial Influences on the Mammalian Intestinal Stem Cell Niche. Stem Cells International, 2017, 5604727. https://doi.org/10.1155/2017/5604727\
  12. Yu, J., Zhang, Y., Kahkoska, A. R., & Gu, Z. (2017). Bioresponsive transcutaneous patches. Current Opinion in Biotechnology, 48, 28–32. https://doi.org/10.1016/j.copbio.2017.03.001
  13. Hu, X., Zhang, Y., Xie, Z., Jing, X., Bellotti, A., & Gu, Z. (2017). Stimuli-Responsive Polymersomes for Biomedical Applications. Biomacromolecules, 18(3), 649–673. https://doi.org/10.1021/acs.biomac.6b01704
  14. Zhang, Y., Yu, J., Bomba, H. N., Zhu, Y., & Gu, Z. (2016). Mechanical Force-Triggered Drug Delivery. Chemical Reviews, 116(19), 12536–12563. https://doi.org/10.1021/acs.chemrev.6b00369
  15. Douglass, J. D., Dorfman, M. D., & Thaler, J. P. (2017). Glia: silent partners in energy homeostasis and obesity pathogenesis. Diabetologia, 60(2), 226–236. https://doi.org/10.1007/s00125-016-4181-3
  16. Flak, J. N. (2017). A role for leptin-regulated neurocircuitry in subordination stress. Physiology & Behavior, 178, 144–150. https://doi.org/10.1016/j.physbeh.2016.11.019
  17. Bakh, N. A., Cortinas, A. B., Weiss, M. A., Langer, R. S., Anderson, D. G., Gu, Z., … Strano, M. S. (2017). Glucose-responsive insulin by molecular and physical design. Nature Chemistry, 9(10), 937–943. https://doi.org/10.1038/nchem.2857
  18. Hung, Y.-H., & Sethupathy, P. (2018). MicroRNAs in the Mammalian Gut Endocrine Lineage. Endocrinology, 159(2), 866–868. https://doi.org/10.1210/en.2017-03117
  19. Stanley, S. A., & Friedman, J. M. (2018). Electromagnetic Regulation of Cell Activity. Cold Spring Harbor Perspectives in Medicine. https://journals.physiology.org/doi/full/10.1152/ajpendo.00469.2017
  20. Alvarsson, A., & Stanley, S. A. (2018). Remote control of glucose-sensing neurons to analyze glucose metabolism. American Journal of Physiology. Endocrinology and Metabolism, 315(3), E327–E339. https://doi.org/10.1152/ajpendo.00469.2017
  21. Devarakonda, K., & Stanley, S. (2018). Investigating metabolic regulation using targeted neuromodulation. Annals of the New York Academy of Sciences, 1411(1), 83–95. https://doi.org/10.1111/nyas.13468
  22. Chen, Z., Hu, Q., & Gu, Z. (2018). Leveraging Engineering of Cells for Drug Delivery. Accounts of Chemical Research, 51(3), 668–677. https://doi.org/10.1021/acs.accounts.7b00526
  23. Yu, J., Zhang, Y., Yan, J., Kahkoska, A. R., & Gu, Z. (2018). Advances in bioresponsive closed-loop drug delivery systems. International Journal of Pharmaceutics, 544(2), 350–357. https://doi.org/10.1016/j.ijpharm.2017.11.064
  24. Ye, Y., Yu, J., Wen, D., Kahkoska, A. R., & Gu, Z. (2018). Polymeric microneedles for transdermal protein delivery. Advanced Drug Delivery Reviews, 127, 106–118. https://doi.org/10.1016/j.addr.2018.01.015
  25. Lawlor, N., & Stitzel, M. L. (2019). (Epi)genomic heterogeneity of pancreatic islet function and failure in type 2 diabetes. Molecular Metabolism, 27S, S15–S24. https://doi.org/10.1016/j.molmet.2019.06.002
  26. White, P. J., & Newgard, C. B. (2019). Branched-chain amino acids in disease. Science (New York, N.Y.), 363(6427), 582–583. https://doi.org/10.1126/science.aav0558
  27. Stanley, S., Moheet, A., & Seaquist, E. R. (2019). Central Mechanisms of Glucose Sensing and Counterregulation in Defense of Hypoglycemia. Endocrine Reviews, 40(3), 768–788. https://doi.org/10.1210/er.2018-00226
  28. Jones, J. I., Nguyen, T. T., Peng, Z., & Chang, M. (2019). Targeting MMP-9 in Diabetic Foot Ulcers. Pharmaceuticals (Basel, Switzerland), 12(2). https://doi.org/10.3390/ph12020079
  29. Kyono, Y., Kitzman, J. O., & Parker, S. C. J. (2019). Genomic annotation of disease-associated variants reveals shared functional contexts. Diabetologia, 62(5), 735–743. https://doi.org/10.1007/s00125-019-4823-3