Original Publications
- Dennis, M. D., Coleman, C. S., Berg, A., Jefferson, L. S., & Kimball, S. R. (2014). REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling. Science Signaling, 7(335), ra68. https://doi.org/10.1126/scisignal.2005103
- Dennis, M. D., Kimball, S. R., Fort, P. E., & Jefferson, L. S. (2015). Regulated in development and DNA damage 1 is necessary for hyperglycemia-induced vascular endothelial growth factor expression in the retina of diabetic rodents. The Journal of Biological Chemistry, 290(6), 3865–3874. https://doi.org/10.1074/jbc.M114.623058
- Quang, D. X., Erdos, M. R., Parker, S. C. J., & Collins, F. S. (2015). Motif signatures in stretch enhancers are enriched for disease-associated genetic variants. Epigenetics & Chromatin, 8, 23. https://doi.org/10.1186/s13072-015-0015-7
- Krishnan, N., Krishnan, K., Connors, C. R., Choy, M. S., Page, R., Peti, W., … Tonks, N. K. (2015). PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. The Journal of Clinical Investigation, 125(8), 3163–3177. https://doi.org/10.1172/JCI80323
- Krishnan, N., Koveal, D., Miller, D. H., Xue, B., Akshinthala, S. D., Kragelj, J., … Tonks, N. K. (2014). Targeting the disordered C terminus of PTP1B with an allosteric inhibitor. Nature Chemical Biology, 10(7), 558–566. https://doi.org/10.1038/nchembio.1528
- Yu, J., Zhang, Y., Ye, Y., DiSanto, R., Sun, W., Ranson, D., … Gu, Z. (2015). Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery. Proceedings of the National Academy of Sciences of the United States of America, 112(27), 8260–8265. https://doi.org/10.1073/pnas.1505405112
- Di, J., Yao, S., Ye, Y., Cui, Z., Yu, J., Ghosh, T. K., … Gu, Z. (2015). Stretch-Triggered Drug Delivery from Wearable Elastomer Films Containing Therapeutic Depots. ACS Nano, 9(9), 9407–9415. https://doi.org/10.1021/acsnano.5b03975
- Di, J., Yu, J., Ye, Y., Ranson, D., Jindal, A., Gu, Z. Engineering Synthetic Insulin-Secreting Cells Using Hyaluronic Acid Microgels Integrated with Glucose-Responsive Nanoparticles. Cellular and Molecular Bioengineering. 2015 (Cover Feature; Young Innovators Special Issue).
- Gao, M., Nguyen, T. T., Suckow, M. A., Wolter, W. R., Gooyit, M., Mobashery, S., & Chang, M. (2015). Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy. Proceedings of the National Academy of Sciences of the United States of America, 112(49), 15226–15231. https://doi.org/10.1073/pnas.1517847112
- Moore, J. A., Miller, W. P., & Dennis, M. D. (2016). Glucosamine induces REDD1 to suppress insulin action in retinal Müller cells. Cellular Signalling, 28(5), 384–390. https://doi.org/10.1016/j.cellsig.2016.01.017
- Delong, T., Wiles, T. A., Baker, R. L., Bradley, B., Barbour, G., Reisdorph, R., … Haskins, K. (2016). Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. Science (New York, N.Y.), 351(6274), 711–714. https://doi.org/10.1126/science.aad2791
- Miller, W. P., Mihailescu, M. L., Yang, C., Barber, A. J., Kimball, S. R., Jefferson, L. S., & Dennis, M. D. (2016). The Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual Dysfunction. Investigative Ophthalmology & Visual Science, 57(3), 1327–1337. https://doi.org/10.1167/iovs.15-18719
- Soares, M. A., Cohen, O. D., Low, Y. C., Sartor, R. A., Ellison, T., Anil, U., … Ceradini, D. J. (2016). Restoration of Nrf2 Signaling Normalizes the Regenerative Niche. Diabetes, 65(3), 633–646. https://doi.org/10.2337/db15-0453
- Ye, Y., Yu, J., Wang, C., Nguyen, N.-Y., Walker, G. M., Buse, J. B., & Gu, Z. (2016). Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery. Advanced Materials (Deerfield Beach, Fla.), 28(16), 3115–3121. https://doi.org/10.1002/adma.201506025
- Szodoray, P., Stanford, S. M., Molberg, Ø., Munthe, L. A., Bottini, N., & Nakken, B. (2016). T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity. The Journal of Allergy and Clinical Immunology, 138(3), 839-851.e8. https://doi.org/10.1016/j.jaci.2016.01.035
- Scott, L. J., Erdos, M. R., Huyghe, J. R., Welch, R. P., Beck, A. T., Wolford, B. N., … Parker, S. C. J. (2016). The genetic regulatory signature of type 2 diabetes in human skeletal muscle. Nature Communications, 7, 11764. https://doi.org/10.1038/ncomms11764
- Powe, C. E., Allard, C., Battista, M.-C., Doyon, M., Bouchard, L., Ecker, J. L., … Hivert, M.-F. (2016). Heterogeneous Contribution of Insulin Sensitivity and Secretion Defects to Gestational Diabetes Mellitus. Diabetes Care, 39(6), 1052–1055. https://doi.org/10.2337/dc15-2672
- White, P. J., Lapworth, A. L., An, J., Wang, L., McGarrah, R. W., Stevens, R. D., … Newgard, C. B. (2016). Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export. Molecular Metabolism, 5(7), 538–551. https://doi.org/10.1016/j.molmet.2016.04.006
- Tang, J. C., Drokhlyansky, E., Etemad, B., Rudolph, S., Guo, B., Wang, S., … Cepko, C. L. (2016). Detection and manipulation of live antigen-expressing cells using conditionally stable nanobodies. ELife, 5. https://doi.org/10.7554/eLife.15312
- Peck, B. C. E., Sincavage, J., Feinstein, S., Mah, A. T., Simmons, J. G., Lund, P. K., & Sethupathy, P. (2016). miR-30 Family Controls Proliferation and Differentiation of Intestinal Epithelial Cell Models by Directing a Broad Gene Expression Program That Includes SOX9 and the Ubiquitin Ligase Pathway. The Journal of Biological Chemistry, 291(31), 15975–15984. https://doi.org/10.1074/jbc.M116.733733
- Zimmerman, C. A., Lin, Y.-C., Leib, D. E., Guo, L., Huey, E. L., Daly, G. E., … Knight, Z. A. (2016). Thirst neurons anticipate the homeostatic consequences of eating and drinking. Nature, 537(7622), 680–684. https://doi.org/10.1038/nature18950
- Fuchsberger, C., Flannick, J., Teslovich, T. M., Mahajan, A., Agarwala, V., Gaulton, K. J., … McCarthy, M. I. (2016). The genetic architecture of type 2 diabetes. Nature, 536(7614), 41–47. https://doi.org/10.1038/nature18642
- Leib, D. E., & Knight, Z. A. (2016). Rapid Sensing of Dietary Amino Acid Deficiency Does Not Require GCN2. Cell Reports, 16(8), 2051–2052. https://doi.org/10.1016/j.celrep.2016.08.022
- Chen, Y., Lin, Y.-C., Zimmerman, C. A., Essner, R. A., & Knight, Z. A. (2016). Hunger neurons drive feeding through a sustained, positive reinforcement signal. ELife, 5. https://doi.org/10.7554/eLife.18640
- Kimball, S. R., Gordon, B. S., Moyer, J. E., Dennis, M. D., & Jefferson, L. S. (2016). Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation. Cellular Signalling, 28(8), 896–906. https://doi.org/10.1016/j.cellsig.2016.03.008
- Kim, H.-E., Grant, A. R., Simic, M. S., Kohnz, R. A., Nomura, D. K., Durieux, J., … Dillin, A. (2016). Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response. Cell, 166(6), 1539-1552.e16. https://doi.org/10.1016/j.cell.2016.08.027
- Tan, C. L., Cooke, E. K., Leib, D. E., Lin, Y.-C., Daly, G. E., Zimmerman, C. A., & Knight, Z. A. (2016). Warm-Sensitive Neurons that Control Body Temperature. Cell, 167(1), 47-59.e15. https://doi.org/10.1016/j.cell.2016.08.028
- Gwiazda, K. S., Grier, A. E., Sahni, J., Burleigh, S. M., Martin, U., Yang, J. G., … Scharenberg, A. M. (2016). High Efficiency CRISPR/Cas9-mediated Gene Editing in Primary Human T-cells Using Mutant Adenoviral E4orf6/E1b55k “Helper” Proteins. Molecular Therapy: The Journal of the American Society of Gene Therapy, 24(9), 1570–1580. https://doi.org/10.1038/mt.2016.105
- Cardenas, A., Allard, C., Doyon, M., Houseman, E. A., Bakulski, K. M., Perron, P., … Hivert, M.-F. (2016). Validation of a DNA methylation reference panel for the estimation of nucleated cells types in cord blood. Epigenetics, 11(11), 773–779.
- Babon, J. A. B., DeNicola, M. E., Blodgett, D. M., Crèvecoeur, I., Buttrick, T. S., Maehr, R., … Kent, S. C. (2016). Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nature Medicine, 22(12), 1482–1487. https://doi.org/10.1038/nm.4203
- Cardenas, A., Allard, C., Doyon, M., Houseman, E. A., Bakulski, K. M., Perron, P., … Hivert, M.-F. (2016). Validation of a DNA methylation reference panel for the estimation of nucleated cells types in cord blood. Epigenetics, 11(11), 773–779. https://doi.org/10.1080/15592294.2016.1233091
- Black, A. J., Gordon, B. S., Dennis, M. D., Jefferson, L. S., & Kimball, S. R. (2016). Regulation of protein and mRNA expression of the mTORC1 repressor REDD1 in response to leucine and serum. Biochemistry and Biophysics Reports, 8, 296–301. https://doi.org/10.1016/j.bbrep.2016.10.003
- Patenaude, J., Lacerte, G., Lacroix, M., Guillemette, L., Allard, C., Doyon, M., … Hivert, M.-F. (2017). Associations of Maternal Leptin with Neonatal Adiposity Differ according to Pregravid Weight. Neonatology, 111(4), 344–352. https://doi.org/10.1159/000454756
- Hu, X., Yu, J., Qian, C., Lu, Y., Kahkoska, A. R., Xie, Z., … Gu, Z. (2017). H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery. ACS Nano, 11(1), 613–620. https://doi.org/10.1021/acsnano.6b06892
- Douglass, J. D., Dorfman, M. D., Fasnacht, R., Shaffer, L. D., & Thaler, J. P. (2017). Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation. Molecular Metabolism, 6(4), 366–373. https://doi.org/10.1016/j.molmet.2017.01.010
- Miller, W. P., Ravi, S., Martin, T. D., Kimball, S. R., & Dennis, M. D. (2017). Activation of the Stress Response Kinase JNK (c-Jun N-terminal Kinase) Attenuates Insulin Action in Retina through a p70S6K1-dependent Mechanism. The Journal of Biological Chemistry, 292(5), 1591–1602. https://doi.org/10.1074/jbc.M116.760868
- Choy, M. S., Li, Y., Machado, L. E. S. F., Kunze, M. B. A., Connors, C. R., Wei, X., … Peti, W. (2017). Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery. Molecular Cell, 65(4), 644-658.e5. https://doi.org/10.1016/j.molcel.2017.01.014
- Peck, B. C. E., Mah, A. T., Pitman, W. A., Ding, S., Lund, P. K., & Sethupathy, P. (2017). Functional Transcriptomics in Diverse Intestinal Epithelial Cell Types Reveals Robust MicroRNA Sensitivity in Intestinal Stem Cells to Microbial Status. The Journal of Biological Chemistry, 292(7), 2586–2600. https://doi.org/10.1074/jbc.M116.770099
- Dorfman, M. D., Krull, J. E., Douglass, J. D., Fasnacht, R., Lara-Lince, F., Meek, T. H., … Thaler, J. P. (2017). Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice. Nature Communications, 8, 14556. https://doi.org/10.1038/ncomms14556
- Varshney, A., Scott, L. J., Welch, R. P., Erdos, M. R., Chines, P. S., Narisu, N., … Stitzel, M. L. (2017). Genetic regulatory signatures underlying islet gene expression and type 2 diabetes. Proceedings of the National Academy of Sciences of the United States of America, 114(9), 2301–2306. https://doi.org/10.1073/pnas.1621192114
- Wiles, T. A., Delong, T., Baker, R. L., Bradley, B., Barbour, G., Powell, R. L., … Haskins, K. (2017). An insulin-IAPP hybrid peptide is an endogenous antigen for CD4 T cells in the non-obese diabetic mouse. Journal of Autoimmunity, 78, 11–18. https://doi.org/10.1016/j.jaut.2016.10.007
- Dorfman, M. D., Krull, J. E., Scarlett, J. M., Guyenet, S. J., Sajan, M. P., Damian, V., … Thaler, J. P. (2017). Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity. Diabetes, 66(4), 920–934. https://doi.org/10.2337/db16-0482
- Machado, L. E. S. F., Shen, T.-L., Page, R., & Peti, W. (2017). The KIM-family protein-tyrosine phosphatases use distinct reversible oxidation intermediates: Intramolecular or intermolecular disulfide bond formation. The Journal of Biological Chemistry, 292(21), 8786–8796. https://doi.org/10.1074/jbc.M116.774174
- Wang, C., Ye, Y., Sun, W., Yu, J., Wang, J., Lawrence, D. S., … Gu, Z. (2017). Red Blood Cells for Glucose-Responsive Insulin Delivery. Advanced Materials (Deerfield Beach, Fla.), 29(18). https://doi.org/10.1002/adma.201606617
- Hivert, M.-F., Scholtens, D. M., Allard, C., Nodzenski, M., Bouchard, L., Brisson, D., … Lowe, W. L. (2017). Genetic determinants of adiponectin regulation revealed by pregnancy. Obesity (Silver Spring, Md.), 25(5), 935–944. https://doi.org/10.1002/oby.21805
- Stanford, S. M., Aleshin, A. E., Zhang, V., Ardecky, R. J., Hedrick, M. P., Zou, J., … Bottini, N. (2017). Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nature Chemical Biology, 13(6), 624–632. https://doi.org/10.1038/nchembio.2344
- Rabbani, P. S., Zhou, A., Borab, Z. M., Frezzo, J. A., Srivastava, N., More, H. T., … Ceradini, D. J. (2017). Novel lipoproteoplex delivers Keap1 siRNA based gene therapy to accelerate diabetic wound healing. Biomaterials, 132, 1–15. https://doi.org/10.1016/j.biomaterials.2017.04.001
- Pereira, M. M. A., Mahú, I., Seixas, E., Martinéz-Sánchez, N., Kubasova, N., Pirzgalska, R. M., … Domingos, A. I. (2017). A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages. Nature Communications, 8, 14967. https://doi.org/10.1038/ncomms14967
- Valdearcos, M., Douglass, J. D., Robblee, M. M., Dorfman, M. D., Stifler, D. R., Bennett, M. L., … Koliwad, S. K. (2017). Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility. Cell Metabolism, 26(1), 185-197.e3. https://doi.org/10.1016/j.cmet.2017.05.015
- Riera, C. E., Tsaousidou, E., Halloran, J., Follett, P., Hahn, O., Pereira, M. M. A., … Dillin, A. (2017). The Sense of Smell Impacts Metabolic Health and Obesity. Cell Metabolism, 26(1), 198-211.e5. https://doi.org/10.1016/j.cmet.2017.06.015
- Flak, J. N., Arble, D., Pan, W., Patterson, C., Lanigan, T., Goforth, P. B., … Myers, M. G. (2017). A leptin-regulated circuit controls glucose mobilization during noxious stimuli. The Journal of Clinical Investigation, 127(8), 3103–3113. https://doi.org/10.1172/JCI90147
- Wheeler, E., Leong, A., Liu, C.-T., Hivert, M.-F., Strawbridge, R. J., Podmore, C., … Meigs, J. B. (2017). Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. PLoS Medicine, 14(9), e1002383. https://doi.org/10.1371/journal.pmed.1002383
- Yan, X., Wang, Z., Westberg-Rasmussen, S., Tarbier, M., Rathjen, T., Tattikota, S. G., … Poy, M. N. (2017). Differential Impact of Glucose Administered Intravenously and Orally on Circulating miR-375 Levels in Human Subjects. The Journal of Clinical Endocrinology and Metabolism, 102(10), 3749–3755. https://doi.org/10.1210/jc.2017-01365
- Sharp, G. C., Salas, L. A., Monnereau, C., Allard, C., Yousefi, P., Everson, T. M., … Relton, C. L. (2017). Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium. Human Molecular Genetics, 26(20), 4067–4085. https://doi.org/10.1093/hmg/ddx290
- Beutler, L. R., Chen, Y., Ahn, J. S., Lin, Y.-C., Essner, R. A., & Knight, Z. A. (2017). Dynamics of Gut-Brain Communication Underlying Hunger. Neuron, 96(2), 461-475.e5. https://doi.org/10.1016/j.neuron.2017.09.043
- Choy, M. S., Swingle, M., D’Arcy, B., Abney, K., Rusin, S. F., Kettenbach, A. N., … Peti, W. (2017). PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors. Journal of the American Chemical Society, 139(49), 17703–17706. https://doi.org/10.1021/jacs.7b09368
- Flannick, J., Fuchsberger, C., Mahajan, A., Teslovich, T. M., Agarwala, V., Gaulton, K. J., … McCarthy, M. I. (2017). Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 4, 170179. https://doi.org/10.1038/sdata.2017.179
- Machado, L. E. S. F., Page, R., & Peti, W. (2018). 1H, 15N and 13C sequence specific backbone assignment of the vanadate inhibited hematopoietic tyrosine phosphatase. Biomolecular NMR Assignments, 12(1), 5–9. https://doi.org/10.1007/s12104-017-9770-7
- Miller, W. P., Yang, C., Mihailescu, M. L., Moore, J. A., Dai, W., Barber, A. J., & Dennis, M. D. (2018). Deletion of the Akt/mTORC1 Repressor REDD1 Prevents Visual Dysfunction in a Rodent Model of Type 1 Diabetes. Diabetes, 67(1), 110–119. https://doi.org/10.2337/db17-0728
- Zillikens, M. C., Demissie, S., Hsu, Y.-H., Yerges-Armstrong, L. M., Chou, W.-C., Stolk, L., … Kiel, D. P. (2017). Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nature Communications, 8(1), 80. https://doi.org/10.1038/s41467-017-00031-7
- Roman, T. S., Cannon, M. E., Vadlamudi, S., Buchkovich, M. L., Wolford, B. N., Welch, R. P., … Mohlke, K. L. (2017). A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus. Diabetes, 66(9), 2521–2530. https://doi.org/10.2337/db17-0464
- Leib, D. E., Zimmerman, C. A., Poormoghaddam, A., Huey, E. L., Ahn, J. S., Lin, Y.-C., … Knight, Z. A. (2017). The Forebrain Thirst Circuit Drives Drinking through Negative Reinforcement. Neuron, 96(6), 1272-1281.e4. https://doi.org/10.1016/j.neuron.2017.11.041
- Chen, Z., Wang, J., Sun, W., Archibong, E., Kahkoska, A. R., Zhang, X., … Gu, Z. (2018). Synthetic beta cells for fusion-mediated dynamic insulin secretion. Nature Chemical Biology, 14(1), 86–93. https://doi.org/10.1038/nchembio.2511
- Nguyen, T. T., Ding, D., Wolter, W. R., Champion, M. M., Hesek, D., Lee, M., … Chang, M. (2018). Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers. European Journal of Pharmacology, 834, 77–83. https://doi.org/10.1016/j.ejphar.2018.07.014
- White, P. J., McGarrah, R. W., Grimsrud, P. A., Tso, S.-C., Yang, W.-H., Haldeman, J. M., … Newgard, C. B. (2018). The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase. Cell Metabolism, 27(6), 1281-1293.e7. https://doi.org/10.1016/j.cmet.2018.04.015
- Rabbani, P. S., Ellison, T., Waqas, B., Sultan, D., Abdou, S., David, J. A., … Ceradini, D. J. (2018). Targeted Nrf2 activation therapy with RTA 408 enhances regenerative capacity of diabetic wounds. Diabetes Research and Clinical Practice, 139, 11–23. https://doi.org/10.1016/j.diabres.2018.02.021
- Fang, C., Zhong, H., Lin, Y., Chen, B., Han, M., Ren, H., … Li, J. (2018). Assessment of the cPAS-based BGISEQ-500 platform for metagenomic sequencing. GigaScience, 7(3), 1–8. https://doi.org/10.1093/gigascience/gix133
- Luber, J. M., Tierney, B. T., Cofer, E. M., Patel, C. J., & Kostic, A. D. (2018). Aether: leveraging linear programming for optimal cloud computing in genomics. Bioinformatics (Oxford, England), 34(9), 1565–1567. https://doi.org/10.1093/bioinformatics/btx787
- Pan, W., Adams, J. M., Allison, M. B., Patterson, C., Flak, J. N., Jones, J., … Myers, M. G. (2018). Essential Role for Hypothalamic Calcitonin Receptor‒Expressing Neurons in the Control of Food Intake by Leptin. Endocrinology, 159(4), 1860–1872. https://doi.org/10.1210/en.2017-03259
- Meek, T. H., Matsen, M. E., Faber, C. L., Samstag, C. L., Damian, V., Nguyen, H. T., … Morton, G. J. (2018). In Uncontrolled Diabetes, Hyperglucagonemia and Ketosis Result From Deficient Leptin Action in the Parabrachial Nucleus. Endocrinology, 159(4), 1585–1594. https://doi.org/10.1210/en.2017-03199
- Kycia, I., Wolford, B. N., Huyghe, J. R., Fuchsberger, C., Vadlamudi, S., Kursawe, R., … Stitzel, M. L. (2018). A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression. American Journal of Human Genetics, 102(4), 620–635. https://doi.org/10.1016/j.ajhg.2018.02.020
- Dai, W., Dierschke, S. K., Toro, A. L., & Dennis, M. D. (2018). Consumption of a high fat diet promotes protein O-GlcNAcylation in mouse retina via NR4A1-dependent GFAT2 expression. Biochimica Et Biophysica Acta. Molecular Basis of Disease, 1864(12), 3568–3576. https://doi.org/10.1016/j.bbadis.2018.09.006
- Dai, W., Miller, W. P., Toro, A. L., Black, A. J., Dierschke, S. K., Feehan, R. P., … Dennis, M. D. (2018). Deletion of the stress-response protein REDD1 promotes ceramide-induced retinal cell death and JNK activation. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, fj201800413RR. https://doi.org/10.1096/fj.201800413RR
- Taylor, D. L., Knowles, D. A., Scott, L. J., Ramirez, A. H., Casale, F. P., Wolford, B. N., … Collins, F. S. (2018). Interactions between genetic variation and cellular environment in skeletal muscle gene expression. PloS One, 13(4), e0195788. https://doi.org/10.1371/journal.pone.0195788
- Zou, L. S., Erdos, M. R., Taylor, D. L., Chines, P. S., Varshney, A., McDonnell Genome Institute, … Didion, J. P. (2018). BoostMe accurately predicts DNA methylation values in whole-genome bisulfite sequencing of multiple human tissues. BMC Genomics, 19(1), 390. https://doi.org/10.1186/s12864-018-4766-y
- Orchard, P., White, J. S., Thomas, P. E., Mychalowych, A., Kiseleva, A., Hensley, J., … Keegan, C. E. (2018). Genome-wide chromatin accessibility and transcriptome profiling show minimal epigenome changes and coordinated transcriptional dysregulation of hedgehog signaling in Danforth’s short tail mice. Human Molecular Genetics. https://doi.org/10.1093/hmg/ddy378
- Powe, C. E., Nodzenski, M., Talbot, O., Allard, C., Briggs, C., Leya, M. V., … Hivert, M.-F. (2018). Genetic Determinants of Glycemic Traits and the Risk of Gestational Diabetes Mellitus. Diabetes. https://doi.org/10.2337/db18-0203
- Cardenas, A., Gagné-Ouellet, V., Allard, C., Brisson, D., Perron, P., Bouchard, L., & Hivert, M.-F. (2018). Placental DNA Methylation Adaptation to Maternal Glycemic Response in Pregnancy. Diabetes, 67(8), 1673–1683. https://doi.org/10.2337/db18-0123
- Keith, B. P., Barrow, J. B., Toyonaga, T., Kazgan, N., O’Connor, M. H., Shah, N. D., … Sheikh, S. Z. (2018). Colonic epithelial miR-31 associates with the development of Crohn’s phenotypes. JCI Insight, 3(19). https://doi.org/10.1172/jci.insight.122788
- Nguyen, T. T., Ding, D., Wolter, W. R., Pérez, R. L., Champion, M. M., Mahasenan, K. V., … Chang, M. (2018). Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing. Journal of Medicinal Chemistry, 61(19), 8825–8837. https://doi.org/10.1021/acs.jmedchem.8b01005
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Reviews
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